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Head Start ® Grapefruit PECTIN Cholesterol Reduction Diet supplement tablets each contain 1,000 mg of pure grapefruit pectin. Medical studies have shown that serum cholesterol levels are reduced by a daily diet containing significant amounts of pectin. By supplementing your daily diet with our pectin from fresh grapefruit rinds you can derive the benefits of pure grapefruit pectin in this convenient tablet form.
Robert E Kowalski, author of The Revolutionary Cholesterol Breakthrough : How to Eat Everything You Want and Have Your Heart Thank You for It states on Page 75 under Chapter 6 "The Soluble Solution":
"IN THE MOOD FOR SOME GRAPEFRUIT RINDS?
"A few years ago a researcher at the University of Florida got a lot of publicity when he found that pectin derived from grapefruit rinds had a powerful cholesterol-lowering effect. Of course, not too many people started eating grapefruit rinds!
"Dr James Cerda continued his research and found some truly amazing results with the swine he used as experimental animals because their hearts and blood vessels are so similar to ours. When they were fed a high-fat diet, those pigs developed severe atherosclerosis. The research included directly examining the insides of the pigs' aortas and arteries after they were slaughtered, which would be impossible to do with humans. Not many humans will volunteer for that!
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Dear Pharmacist . . . Why is everybody picking on my favorite fruit juice? My pharmacist just told me not to drink grapefruit anymore because I take diltiazem. What will happen if I combine the two?
--CC Ft. Lauderdale, Florida-- Nothing in your case. But this grapefruit interaction story has been twisted and turned so many times that it is creating unjustifiable public fear. I'll say it outright. Serious drug interactions with grapefruit are very rare. That said, diltiazem does interact with the red fleshy fruit, but it is almost negligible. You don't have to switch medication or give up grapefruit. Speak to your doctor or pharmacist about switching medicine if you're really devoted to grapefruits. The public went sour on grapefruit years ago after inaccurate reports. There are millions of interactions with drugs and foods. Grapefruit just happens to keep making the news. People need to remember that grapefruit contains lycopene, which is very protective to the prostate. How sweet it is! In fact, citrus is loaded with vitamin C and a substance called limonoids. Preliminary research on limonoids shows that it can prevent and halt cancer under laboratory conditions. How sweet it is. Soon, there will be tests in humans, but do we need data to tell us that fruits are good for us? Most of the medications that interact with grapefruit do so only to a small or negligible extent. And a lot of factors come into play. For example, what type of medicine you take matters. There are only a handful that might pose a serious problem at this time. Those include 2 cholesterol-lowering statins Mevacor and Zocor, the anti-anxiety drug Buspar (buspirone), the allergy drug Hismanal and the heart rhythm drug Cordarone (amiodarone.) These drugs definitely interact with grapefruit juice and should not be combined. Some drugs interact at a moderate level, but can be taken safely. You just need to remain consistent with your food and beverage intake. Your body will adjust. In fact, because grapefruit tends to make most drugs work more potently, it may just be that you need a lower dosage of medication. Moderately interacting drugs include sedatives such as Ambien and Valium, blood pressure meds like DynaCirc, Procardia (nifedipine) and Plendil. Also, Claritin, Viagra and Tegretol (carbamazepine.) Sometimes grapefruit lowers absorption of certain medications. But this is also very rare and only happens with vinblastine, cyclosporine, Cozaar, Lanoxin (digoxin) and Allegra. Again, approach with caution, not panic. Reactions differ depending on the manufacturer's preparation of grapefruit juice and also on the health of your innards. Your body readjusts its settings to your medication, even if it interacts with grapefruit juice. By and large, most of the drugs on the market today do not interact with grapefruit in any dangerous way. So if you love grapefruit, go ahead slurp it up, it's good for you. --Suzy-- This information is opinion only. It is not intended to treat, cure or diagnose your condition. Always consult your physician about changes to your health plan. |
"We have demonstrated that grapefruit pectin:
(1) significantly lowers the plasma cholesterol levels (*p<0.01);
(2) improves LDLC and HDLC ratio; and does not affect triglycerides."
Current US Dietary Guidelines recommend increased fiber in our diets and the National Institute of Health data shows that fiber itself can reduce incidences of cancer, heart disease, hypertension, obesity and diabetes. Dietary fiber comes from the cell walls of plants, such as grains, nuts, beans, vegetables and fruits, and includes cellulose, lignin, pectins and gums in its composition.
The parts of the grapefruit which do the most to aid in cholesterol reduction are found in the rind and membranes surrounding the sections, the parts normally thrown away and not eaten. We use this beneficial grapefruit pectin by-product of grapefruit processing to give you the best part of the fruit in convenient tablet form. The recommended dosage is one tablet four times daily: one with each of your three daily meals and the fourth at bedtime.
Barry Sears PhD author of "The Top 100 Zone Foods" states on Page 84:
" ... Grapefruit also contains pectin, a soluble fiber that reduces the rate of entry of carbohydrates into your bloodstream, thereby lowering insulin secretion.
"Grapefruit and other citrus fruits also protect against cancer. In Japanese studies, grapefruit extract stopped tumor growth after it was injected under the skin of mice. The researchers concluded that grapefruit is a 'remarkable anti-mutagen', a substance that reverses cellular changes that lead to the division and growth of cancer cells.
"To maximize the heart benefits, be sure to eat the grapefruit pulp, which includes the membranes that separate the sections and the white interior of the rind. These are the areas that contain pectin, and that's why grapefruit juice (which has none of this pulp) is not high in pectin and doesn't lower cholesterol levels."
We have found over the years that most people are more comfortable taking grapefruit pectin as a supplement, rather than eating the rather dry, tasetless and pulpy membranes of the grapefruit rind, as it is a more palatable and dependable way to get the valuable pectin your body needs.
For Weight-Loss plus Cholesterol Control click here # 090 GreatFruit ® Fat Burner Diet with Niacin
Grapefruit Pectin Research Abstracts
Grapefruit PECTIN Tablets 60s
The Cholesterol Reduction Diet

Inhibition of Atherosclerosis by Dietary Pectin in Microswine With Sustained Hypercholesterolemia: James J. Cerda, MD; Signurd J. Normann, MD, PhD; Michael P. Sullivan, MS; Charles W. Burgin; Frank L. Robbins, BS; Sohini Vathada, MD; Paisan Leelachaikul, MD
Abstract "Sustained hypercholesterolemia is a known risk factor for development of atherosclerosis. In animal studies, grapefruit pectin fed concurrently with a high-lipid diet inhibits hypercholesterolemia and atherogenesis. The purpose of the present study was to determine if grapefruit pectin affects cholesterol levels and atherogenesis of animals with established hypercholesterolemia. Micro swine were fed an atherogenic diet to establish hypercholesterolemia. Plasma cholesterol levels rose rapidly and for 360 days were sustained at levels 6 to 12 fold the normal level. Then, half the micro swine, selected at random, were fed a diet in which 3% grapefruit pectin was substituted for cellulose, and the remaining animals received the original diet. Animals were killed 270 days later, and the extent of atherosclerosis was determined. In animals with established hypercholesterolemia, pectin did not lower their cholesterol levels. However, pectin reduced the extent of atherosclerosis in both the aorta and coronary arteries. The mean surface area covered by atherosclerosis in the aorta was 13.6% in the group that did not receive pectin compared with 5.3% in the group that did receive pectin. The mean coronary artery narrowing was 45% without pectin and 24% with pectin. We conclude that pectin may have a direct beneficial effect on atherosclerosis by a mechanism independent of cholesterol levels". (Circulation. 1994;89:1247-1253.)
The Effects of Grapefruit Pectin on Patients at Risk for Coronary Heart Disease Without Altering Diet or Lifestyle: J. J. Cerda, MD, F.L. Robbins, BS, C.W. Burgin, T.G. Baumgartner, Pharm D., R.W. Rice, BA; Division of Gastroenterology / Hepatology / Nutrition, University of Florida College of Medicine, Gainesville, FL USA
"This study has shown that daily dietary supplementation of 15 grams of grapefruit pectin significantly lowered plasma cholesterol and improved the ratio of LDLC:HDLC in hypercholesterolemia patients who are unable or unwilling to follow a low-risk diet". Clinical Cardiology. 11. 589-594 (1988)
THE PECTIN-CHOLESTEROL CONNECTION - A REVIEW: James J. Cerda, MD; Division of Gastroenterology / Hepatology / Nutrition, University of Florida College of Medicine and the Veterans Affairs Medical Center, Gainesville, FL USA
"In vitro techniques have been developed to systematically study dietary grapefruit pectin. The effectiveness of grapefruit in lowering plasma cholesterol both in miniature swine and in human studies has been assessed. Recently the effects of grapefruit pectin on cholesterol levels and atherogenesis in animals with established hypercholesterolemia have been assessed. These studies strongly suggest that pectin may have a direct, beneficial effect on atherosclerosis by a mechanism independent of cholesterol levels. Initial studies using the guinea pig model have been highly successful with over a 40% reduction in cholesterol over a six-week period. Therefore, it was concluded that grapefruit pectin and other food sources rich in soluble fibers are useful adjuvants in the treatment of patients with hypercholesterolemia. Enough evidence has accumulated to substantiate that one in four Americans has a cholesterol level that imparts an increased risk of premature coronary heart disease. Therefore, a broader application and a form of recommendations to include pectin-rich foods, pectin protein food supplements, and a prudent diet aimed at the primary prevention of atherosclerosis in the general public now seem justified". Technology: Journal of The Franklin Institute, Vol. 331A, pp. 199-202, 1994
PECTIN: ITS INTERACTION WITH SERUM LIPOPROTEINS: Mirza Mansoor Baig, Ph.D. and James John Cerda, M D; Division of Gastroenterology/Hepatology/Nutrition, University of Florida College of Medicine, Gainesville, FL USA
"The results obtained from the in vitro studies described clearly suggest that pectin interacts specifically with serum LDL and this interaction appears to be of electrostatic in nature. The observed interaction between pectin and LDL appears to be of significant importance since LDL is the major biological carrier of cholesterol and the principal ingredient of atherosclerotic lesions found in diseased cardiovascular tissue". The American Journal of Clinical Nutrition 34: JANUARY 1981, pp . 50-53.
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